Importance of mutual benefits in online knowledge sharing communities

The sustainability of knowledge sharing e-communities is a major issue at present. A hypothesis was proposed at the outset in the paper that the provision of mutual benefits among participants will lead to positive participation. Drawing from the economic and social theories, a framework for analysis was developed and tested in an empirical study. The preliminary results demonstrated a direct relationship between mutual benefits and the level of participation, and hence supported the hypothesis

The integration of grid and peer-to-peer to support scientific collaboration

There have been a number of e-Science projects which address the issues of collaboration within and between scientific communities. Most effort to date focussed on the building of the Grid infrastructure to enable the sharing of huge volume of computational and data resources. The ‘portal’ approach has been used by some to bring the power of grid computing to the desk top of individual researchers. However, collaborative activities within a scientific community are not only confined to the sharing of data or computational intensive resources. There are other forms of sharing which can be better supported by other forms of architecture. In order to provide a more holistic support to a scientific community, this paper proposes a hybrid architecture, which integrates Grid and peer-to-peer technologies using Service Oriented Architecture. This platform will then be used for a semantic architecture which captures characteristics of the data, functional and process requirements for a range of collaborative activities. A combustion chemistry research community is being used as a case study

Collaborative e-science architecture for Reaction Kinetics research community

This paper presents a novel collaborative e-science architecture (CeSA) to address two challenging issues in e-science that arise from the management of heterogeneous distributed environments: (i) how to provide individual scientists an integrated environment to collaborate with each other in distributed, loosely coupled research communities where each member might be using a disparate range of tools; and (ii) how to provide easy access to a range of computationally intensive resources from a desktop. The Reaction Kinetics research community was used to capture the requirements and in the evaluation of the proposed architecture. The result demonstrated the feasibility of the approach and the potential benefits of the CeSA

Use of scenario evaluation in preparation for deployment of a collaborative system for knowledge transfer - the case of KiMERA

This paper presented an approach for the evaluation of a collaborative system, after the completion of system development and software testing but before its deployment. Scenario and collaborative episodes were designed and data collected from users role-playing. This was found to be a useful step in refining the user training, in setting the right level of user expectation when the system started to roll-out to real users and in providing feedback to the development team

Enabling e-Research in combustion research community

Abstract This paper proposes an application of the Collaborative e-Science Architecture (CeSA) to enable e-Research in combustion research community. A major problem of the community is that data required for constructing modelling might already exist but scattered and improperly evaluated. That makes the collection of data for constructing models difficult and time-consuming. The decentralised P2P collaborative environment of the CeSA is well suited to solve this distributed problem. It opens up access to scattered data and turns them to valuable resources. Other issues of the community addressed here are the needs for computational resources, storages and interoperability amongst different data formats can also be addressed by the use of Grid environment in the CeSA

A collaborative e-Science architecture towards a virtual research environment

This paper presents a novel Collaborative e-Science Architecture (CeSA) to address two challenging issues in e-Science that have arisen from the management of heterogeneous distributed environments. By combining the capabilities of peer-to-peer and Grid computing, the architecture provides an environment for scientific collaborations within distributed, loosely coupled research communities and brings computation and data intensive resources to the desktops of the scientists in these communities. The Reaction Kinetics research community had been used as a case study to capture realistic requirements. A prototype based on the architecture was developed for user experiment and evaluation. The results of these experiments were promising. It has provided further motivation to evolve CeSA towards a Virtual Research Environment

A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer.

BACKGROUND: Molecular profiling of the tumour immune microenvironment (TIME) has enabled the rational choice of immunotherapies in some adult cancers. In contrast, the TIME of paediatric cancers is relatively unexplored. We speculated that a more refined appreciation of the TIME in childhood cancers, rather than a reliance on commonly used biomarkers such as tumour mutation burden (TMB), neoantigen load and PD-L1 expression, is an essential prerequisite for improved immunotherapies in childhood solid cancers. METHODS: We combined immunohistochemistry (IHC) with RNA sequencing and whole-genome sequencing across a diverse spectrum of high-risk paediatric cancers to develop an alternative, expression-based signature associated with CD8+ T-cell infiltration of the TIME. Furthermore, we explored transcriptional features of immune archetypes and T-cell receptor sequencing diversity, assessed the relationship between CD8+ and CD4+ abundance by IHC and deconvolution predictions and assessed the common adult biomarkers such as neoantigen load and TMB. RESULTS: A novel 15-gene immune signature, Immune Paediatric Signature Score (IPASS), was identified. Using this signature, we estimate up to 31% of high-risk cancers harbour infiltrating T-cells. In addition, we showed that PD-L1 protein expression is poorly correlated with PD-L1 RNA expression and TMB and neoantigen load are not predictive of T-cell infiltration in paediatrics. Furthermore, deconvolution algorithms are only weakly correlated with IHC measurements of T-cells. CONCLUSIONS: Our data provides new insights into the variable immune-suppressive mechanisms dampening responses in paediatric solid cancers. Effective immune-based interventions in high-risk paediatric cancer will require individualised analysis of the TIME.Chelsea Mayoh, Andrew J. Gifford, Rachael Terry, Loretta M. S. Lau, Marie Wong, Padmashree Rao, Tyler Shai, Hee, Federica Saletta, Dong, Anh Khuong, Quang, Vicky Qin, Marion K. Mateos, Deborah Meyran, Katherine E. Miller, Aysen Yuksel, Emily V. A. Mould, Rachel Bowen, James, Dinisha Govender, Akanksha Senapati, Nataliya Zhukova, Natacha Omer, Hetal Dholaria, Frank Alvaro, Heather Tapp, Yonatan Diamond, Luciano Dalla Pozza, Andrew S. Moore, Wayne Nicholls, Nicholas G. Gottardo, Geoffrey McCowage, Jordan R. Hansford, Seong, Lin Khaw, Paul J. Wood, Daniel Catchpoole, Catherine E. Cottrell, Elaine R. Mardis, Glenn M. Marshall, Vanessa Tyrrell, Michelle Haber, David S. Ziegler, Orazio Vittorio, Joseph A. Trapani, Mark J. Cowley, Paul J. Neeson, and Paul G. Eker

A process view of trust building in virtual organizations

This paper examines the role of trust in a virtual organisation using a process view. Electronic Commerce is used to illustrate the issue of trust building within a business process. The ‘trust as credit’ mentality in Commerce is found more useful than ‘trust as security’ in modeling the dynamic nature of trust building. The paper presents a vision of enabling users to be in better control over the behaviour of ICT systems. To achieve this, we need a model which addresses trust policy and feedback, and makes a distinction between contract and production phases of a business processes

An ontology-based adaptive approach to P2P resource discovery in distributed scientific communities

Resource discovery is a challenge in a distributed environment. Trade-off is often needed between the speed and the accuracy of findings. There are two parts to resource discovery: the routing and matching of a query. This paper presents an adaptive approach to peer-to-peer (P2P) resource discovery which separates the routing of queries from the query matching mechanism. It focuses on improving the efficiency of routing search queries to increase the quality of the search results and also the scalability of the resource discovery in a highly decentralized P2P environment. This separation enables the adoption of any appropriate query matching/processing methods at a later stage. Three properties of scientific research communities provide the grounding for the approach: the existence of common interest groups, the willingness to share resources of common interests and the transitive relationship in the sharing behavior. The use of ontology enables ‘learning’ from past results and for providing guidance in future searches. By exploiting these features, the quality of search results can be improved and the network traffic reduced. Experimental results have provided some evidence to confirm the efficiency gain of this adaptive approach

Use of Virtual Science Park resource rooms to support group work in a learning environment

This paper presents a detailed evaluation on the acceptability of a range of synchronous and asynchronous collaborative tools provided within the Virtual Science Park (VSP) for group work in a learning environment. In this study, the VSP was used to provide a web-based 'Resource Room' adopting the familiar 'folder' metaphor for structuring and linking resources, and a number of different user interfaces for interaction and sharing information. A list of criteria is established for the evaluation. By using scenario testing and structured questionnaires, qualitative feedback was collected from 43 Masters students. The findings reinforce and add to the concerns highlighted in other studies, in particular, the importance for shared awareness, privacy, conventions for interaction and the provision of an effective multimedia environment. More attention will be needed in these areas for effective use of these groupware tools